Use the tablet with your left or your right hand
Some tablets have hardware buttons on one side. The tablet can be rotated 180 degrees to position these buttons. By default, the orientation is for right-handed people. To switch the orientation to left-handed:
Go to the desktop and start typing Wacom Tablet.
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Click on Wacom Tablet to open the panel.
If no tablet is detected, you’ll be asked to Please plug in or turn on your Wacom tablet. Click Bluetooth in the sidebar to connect a wireless tablet.
Set the Left-Handed Orientation switch to on.