Use the tablet left-handed
Some tablets have hardware buttons on one side. The tablet can be rotated 180 degrees to position these buttons for left-handed people. To switch the orientation to left-handed:
Go to the Desktop and start typing Wacom Tablet.
Click on Wacom Tablet to open the panel.
Click the Tablet button in the header bar.
If no tablet is detected, you’ll be asked to Please plug in or turn on your Wacom tablet. Click the Bluetooth Settings link to connect a wireless tablet.
Switch the Left-Handed Orientation switch to on.